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《医学前沿(英文)》 2017年 第11卷 第2期 页码 229-238 doi: 10.1007/s11684-017-0506-y
A CALLG2008 protocol was developed by the Chinese Acute Lymphoblastic Leukemia Cooperative Group for adult acute lymphoblastic leukemia (ALL). We retrospectively analyzed 153 newly diagnosed adult patients with Philadelphia chromosome (Ph)-positive ALL enrolled into imatinib (400 mg/d) plus CALLG2008 regimen between 2009 and 2015. The median age was 40 years (range, 18–68 years), with 81 (52.3%) males. The overall hematologic complete remission (CR) rate was 96.7% after induction. With a median follow-up of 24.2 months, the estimated 3-year overall survival (OS) and event-free survival (EFS) rates were 49.5% (95% confidence interval (CI): 38.5%–59.5%) and 49.2% (95% CI: 38.3%–59.2%), respectively. Fifty-eight (36 with haploidentical donor) patients underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) in first CR. Among the patients in CR1 after induction, both the 3-year OS and EFS were significantly better in the allo-HSCT group than in the without allo-HSCT group (73.2%, 95% CI: 58.3%–83.5% vs. 22.2%, 95% CI: 8.7%–39.6% and 66.5%, 95% CI: 50.7%–78.2% vs. 16.1%, 95% CI: 5.1%–32.7%, respectively). Multivariate analysis showed that allo-HSCT and achievement of major molecular response were associated with favorable OS or EFS independently. Interestingly, in the allo-HSCT cohort, the donor type (haploidentical versus matched donors) had no significant impact on EFS or OS. All these results suggested that imatinib plus CALLG2008 was an effective protocol for Ph-positive ALL. Haploidentical donors can also be a reasonable alternative expedient donor pool.
关键词: Philadelphia chromosome acute lymphoblastic leukemia imatinib CALLG2008
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《医学前沿(英文)》 2017年 第11卷 第3期 页码 440-444 doi: 10.1007/s11684-017-0523-x
Philadelphia chromosome-positive acute myeloid leukemia is controversial and difficult to distinguish from the blast phase of chronic myeloid leukemia. As a myeloid neoplasm, rare cases of this leukemia manifest multiple soft-tissue tumors or bone lytic lesions. In this paper, we describe a 49-year-old male patient who had an abrupt onset with sharp chest pain, fever, fatigue, emaciation, and splenomegaly. 18F-fluoro-deoxy-glucose positron emission tomography/computed tomography (18F-FDG PET/CT) result showed diffuse and uneven hypermetabolic lesions in the bone marrow with peripheral bone marrow expansion, multiple soft tissue neoplasms with high 18F-FDG uptake, and lytic bone lesions. Bone marrow smear and biopsy detected aberrant blast cells expressing myeloid rather than lymphoid immunophenotype marker. For the existence of Philadelphia chromosome and BCR-ABL1 fusion gene together with complex chromosome abnormalities, a diagnosis of Philadelphia-positive acute myeloid leukemia was made, although the type (de novo or blast crisis) remained unclear.
关键词: Philadelphia chromosome acute myeloid leukemia mass osteolysis positron emission tomography
The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary
QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning
《医学前沿(英文)》 2008年 第2卷 第3期 页码 211-215 doi: 10.1007/s11684-008-0041-y
关键词: sensitive genome-wide prediction genome-wide microsatellite frequency Hepatocellular carcinoma
A bacterial artificial chromosome-based physical map of
Yuhua FU,Zhiqiang XIA,Shujuan WANG,Xin CHEN,Cheng LU,Mingcheng LUO,Hongbin ZHANG,Wenquan WANG
《农业科学与工程前沿(英文)》 2016年 第3卷 第4期 页码 321-329 doi: 10.15302/J-FASE-2016124
余宏亮,常明秀,曹恒海,薄立伟,王艳丽,吴艳红
《中国工程科学》 2014年 第16卷 第5期 页码 67-69
为了了解有不良孕产史夫妇的染色体断裂率的发生情况,笔者对来河南省人口和计划生育科学技术研究院就诊的有不良孕产史夫妇的染色体断裂率分析的检查结果进行统计学分析。分析结果显示:男性患者的就诊年龄平均为29.07 岁,女性患者的就诊年龄平均为28.15 岁,年龄与染色体检测结果间无相关。男性患者中未发现断裂的占男性总数的32.38 %,女性患者中未发现染色体断裂的占女性总数的37.7 %;男性染色体断裂率为1 的占男性总数的38.11 %,女性染色体断裂率为1 的占女性总数的34.43 %;男性染色体断裂率为2 的占男性总数的21.72 %,女性染色体断裂率为2 的占女性总数的23.36 %;男性染色体断裂率为3 的占男性总数的7.79 %,女性染色体断裂率为3 的占女性总数的2.87 %;女性染色体断裂率为4 的占女性总数的0.82 %;女性染色体断裂率为6 的占女性总数的0.41 %;女性染色体断裂率为9 的占女性总数的0.41 %。男性患者的染色体断裂率均值无差别(P>0.05)。男、女患者的染色体断裂率均值在1.01,患者平均年龄为29.53 岁,经检查有染色体断裂占64.96 %。通过研究发现,染色体断裂率增高可能是引起夫妇中发生胎停、流产、胎儿发育不良等不良孕产现象的重要原因之一。
Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken
Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 242-249 doi: 10.15302/J-FASE-2014018
关键词: sex-linked inhibitor of dermal melanin (Id) Silkie chromosome Z
Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice
Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI
《农业科学与工程前沿(英文)》 2014年 第1卷 第3期 页码 179-184 doi: 10.15302/J-FASE-2014020
关键词: recombinant human butyrylcholinesterase (rhBCHE) human lactoferrin bacterial artificial chromosome (hLF BAC) transgenic mice milk
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《医学前沿(英文)》 2018年 第12卷 第3期 页码 324-329 doi: 10.1007/s11684-017-0558-z
Splenic lymphoma with villous lymphocytes (SLVL) or splenic marginal zone lymphoma with circulating villous lymphocytes is rare, and prolymphocytic transformation of SLVL is rarer. At present, only one case of SLVL with t(8;14)(q24;q32) translocation has been reported. In this study, we report a case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) chromosome translocation that we inclined to SLVL with a prolymphocytic transformation. A 73-year-old female showed marked hepatosplenomegaly and high lymphocytosis (lymphocytes>200×109/L). The abnormal lymphocytes had short coarse villi and round nuclei with prominent nucleoli. The immunophenotypes showed CD19+, CD20+, HLA-DR+, CD22+, CD5+, Kappa+, CD25dim, CD71dim, Lambda−, CD7−, CD10−, CD23−, CD34−, CD33−, CD13−, CD14−, CD117−, CD64−, CD103−, and CD11c−. The karyotype showed complex abnormality: 46XX,+3,−10, t(8;14)(q24;q32)[11]/46XX[9]. The cytoplasmic projection, immunological characteristics, and trisomy 3 chromosome abnormality supported the diagnosis of SLVL. However, the presence of prominent nucleoli and high lymphocytosis suggested prolymphocytic transformation, probably as a result of t(8,14) chromosome translocation. In this report, we described an unusual case of B-lymphoproliferative disorder with villous lymphocytes harboring t(8;14)(q24;q32) translocation, which could provide help in the diagnosis and differential diagnosis of B-lymphocytic proliferative diseases.
关键词: splenic lymphoma with villous lymphocytes splenic marginal zone lymphoma transformation chromosome translocation
标题 作者 时间 类型 操作
Efficacy and prognostic factors of imatinib plus CALLG2008 protocol in adult patients with newly diagnosed Philadelphiachromosome-positive acute lymphoblastic leukemia
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期刊论文
Philadelphia chromosome-positive acute myeloid leukemia with masses and osteolytic lesions: finding of
null
期刊论文
The predictive value of chromosome 8p deletion for metastasis of hepatocellular carcinoma: a summary
QIN Lunxiu, TANG Zhaoyou, GUAN Xinyuan, YE Qinghai, JIA Huliang, REN Ning
期刊论文
A bacterial artificial chromosome-based physical map of
Yuhua FU,Zhiqiang XIA,Shujuan WANG,Xin CHEN,Cheng LU,Mingcheng LUO,Hongbin ZHANG,Wenquan WANG
期刊论文
Genomic regions associated with the sex-linked inhibitor of dermal melanin in Silkie chicken
Ming TIAN,Rui HAO,Suyun FANG,Yanqiang WANG,Xiaorong GU,Chungang FENG,Xiaoxiang HU,Ning LI
期刊论文
Expression of recombinant human butyrylcholinesterase in the milk of transgenic mice
Dan LU,Shengzhe SHANG,Shen LIU,Ying WU,Fangfang WU,Tan TAN,Qiuyan LI,Yunping DAI,Xiaoxiang HU,Yaofeng ZHAO,Ning LI
期刊论文